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Workshop 3: The Lung and the Respiratory (Structure, Oxygen Transport)(November 6-10, 2006)

Organizers: Ken Lutchen, Jason Bates, and Bela Suki

Computational modeling promises a new era in the fundamental understandings of how lung morphometry and biomechanical/biomaterial properties impact lung function. With continuous improvement in imaging modalities, it is becoming increasingly possible to establish precise physical locations and degrees of structural or functional defects in the lung during disease. Such data will beg the question of how explicit defects of biological components, processes, and structure at specific anatomic locations alter function. Computational power now permits one to develop models that are closer anatomic replicas of a real lung, while incorporating the fundamental biophysical properties and relations for each exquisite component of each airway. Rational and efficient disease management can be enhanced by understanding or predicting how alterations in the individual components of lung structure and properties impact the emergent lung function.

The workshop aims to:

  • indentify critical current questions in asthma, emphysema, and respiratory distress syndrome that can be addressed via mathematical modeling integrated across multiple scales;
  • identify modeling challenges associated with understanding fundamental biology and physiology of the constituent parts of the lung ranging from parencymal, alveolar and airway smooth muscle cells, to airways and alveoli and microvessels in the lung, to lung tissue;
  • identify role imaging can play to advance models of micro and macro structure and to link structure to function via computational models;
  • understand how emergent function and dysfunction in the lung for these diseases relates back to its constituent parts.

Schedule
Monday, November 6
6:30-8:30pm Welcome and reception at the Holiday Inn - Light refreshments will be served.
Tuesday, November 7
Session A: Approaches to modeling the lung
Moderator: Tilo Winkler
9:00-9:20am Ching-Long Lin: Multi-scale Simulation of Pulmonary Air Flow
9:20-9:40am Jason Bates: Modeling emergent behavior
9:40-10:20am General discussion
10:20-10:40am Coffee break
Session B: The role of modeling in the elucidation of lung pathophysiology
10:40-11:00am Brett Simon: Clinical Perspectives: Modeling in Acute Lung Injury
11:00-11:20am Steve George: An Integrative Approach Towards Understanding Nitrogen Oxide Biology in the Lungs
11:20-12:00pm General discussion
12:00-1:30pm Lunch break
Session C: Airways mechanics
Moderator: Rob Tepper
1:30-1:50pm Samir Ghadiali: Fluid-Structure Modeling of Cellular Deformation and Injury in Pulmonary Airways
1:50-2:10pm Wayne Mitzner: Modeling airway distensibility in the lung
2:10-2:50pm General discussion
2:50-3:10pm Coffee break
Session D: Aerosol mixing and deposition
Moderator: Ananth Annapragada
3:10-3:30pm Akira Tsuda: Folding and mixing
3:30-3:50pm Chantal Darquenne: Simulating aerosol deposition in the lung: how realistic are the current models?
3:50-4:30pm General discussion
Wednesday, November 8
Session A: Cell mechanics
Moderator: Susan Gunst
9:00-9:20am Jeff Fredberg: Cytoskeletal remodeling and slow dynamics in the living cell: Are we built of glass?
9:20-9:40am Ben Fabry: Nonlinear viscoelasticity of living cells
9:40-10:20am General discussion
10:20-10:40am Coffee break
Session B: Parenchymal structure and rheology
Moderator: Adam Polak
10:40-11:00am Hiroko Kitaoka: Morphogenesis-based 4D model of the alveolar structure
11:00-11:20am Dimitrije Stamenovic: Micromechanics of the lung: from the parenchyma to the cytoskeleton - the unifying role of distending stress
11:20-12:00pm General discussion
12:00-1:30pm Lunch break
Session C: Lung imaging
Moderator: Mitch Albert
1:30-1:50pm Eric Hoffman: Lung structure from imaging
1:50-2:10pm Michael Sanderson: Video imaging of parenchymal mechanics
2:10-2:50pm General discussion
2:50-3:10pm Coffee break
Session D: Ventilation and perfusion
Moderator: Said Audi
3:10-3:30pm Joe Anderson: Impact of Airway Gas Exchange on the Multiple Inert Gas Elimination Technique
3:30-3:50pm Kim Prisk: Gas mixing in the periphery of the lung: Insights from modeling and microgravity
3:50-4:30pm General discussion
6:30-7:30pm Public Lecture Series: Peter Macklem: Complexity, the Origins of Order and the Respiratory System: A Physician's View
Thursday, November 9
Session A: Modeling the whole lung
Moderator: Anne Clough
9:00-9:20am Ken Lutchen: Modeling lung mechanical function
9:20-9:40am Jose Venegas: Paradoxical airway response to bronchoprovocation, a manifestation of complex system behavior
9:40-10:20am General discussion
10:20-10:40am Coffee break
Session B: The role of modeling in the elucidation of lung pathophysiology
10:40-11:00am Brent McParland: Determinants of hyperresponsiveness: Real Media
11:00-11:20am Geof Maksym: Variation of lung function in asthma at short and long time scales
11:20-12:00pm General discussion
12:00-1:30pm Lunch break
Session C: Bridging between levels of scale
Moderator: Jeff Hammersley
1:30-1:50pm Bela Suki: Hierarchical force transmission in the lung: some modeling results relevant to the normal and emphysematous parenchyma
1:50-2:10pm James Butler: Scale-free methods from physics
2:10-2:50pm General discussion
2:50-3:10pm Coffee break
Session D: Funding opportunities
3:10-3:30pm TBA
3:30-3:50pm TBA
3:50-4:30pm General discussion
6:00-9:00pm Dinner at the Holiday Inn on the Lane
Friday, November 10
Session A: Scale-based breakout groups
9:00-10:30am Micro-scale: molecules to cells
Meso-scale: airways and tissues
Macro-scale: whole organ
10:30-11:00am Coffee Break
Session B: Scale-based group reports
11:00-11:30am Micro-scale group
11:30-12:00pm Meso-scale group
12:00-12:30pm Macro-scale group
12:30-1:15pm Lunch break
Session C: Disease-based breakout groups
1:15pm-2:45pm Asthma, Emphysema/COPD, Lung injury/ARDS
Session D: Disease-based group reports
2:45-3:15pm Asthma group
3:15-3:45pm Emphysema/COPD group
3:45-4:15pm Lung injury/ARDS group
4:15-4:30pm Conclusion