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2004 Summer Program in Cell Processes

This year the program will focus on Cell Processes. The program leader is Professor James Sneyd. After an introductory tutorial and discussion in the first 2 days, the participants will be divided into teams of five, with each team being led by an MBI postdoc. Teams will work on one project for the first 2 1/2 weeks, and there will be a miniconference in the final 2 days.

During the 3-week period there will also be several general talks on cell cycle and proliferation by active researchers and visits to bioscience labs.

 

The following projects will be assigned:

8/19 Thursday 12:30pm - 5:00pm
Project 1
Calcium and Heart Failure: Pranay Goel
Construct a model for a calcium transient in a normal ventricular myocyte, and in heart failure cells that explain the differences in the calcium transients. How does your model cope with calcium overload?

Project 2
Synaptic Plasticity:

Alla Borisyuk

Synaptic transmission and synaptic plasticity.
PPT
Project 3
Cell Cycle and Apoptosis:

Gheorghe Craciun
Construct a model that couples cell cycle and apoptosis.
PPT
8/20 Friday 9:00pm - 12:00pm
Project 4
Olfaction:

Daniel Dougherty
Construct a model of a signal transduction and adaptation in odoreceptors.
Project 5
Calcium Oscillations: Martin Wechselberger
Design a realistic experimental protocol that will determine the role of [IP3] in Ca2+ oscillations in pancreatic acinar cells.

 

Introductory material on these projects will be provided to all participants during the program.

 

Schedule

Week 1

Monday 8/2
9:00-9:05am Welcome (Avner Friedman)
9:05-10:05am Tutorial 1
James Sneyd: Enzyme kinetics - PPT
10:05-10:30am Coffee Break
10:30-11:30am Tutorial 2
James Sneyd: How cells control their volume - PPT
11:30-2:00pm Lunch
2:00-3:00pm Martin Wechselberger: Introduction to Dynamical Systems: Phase analysis and bifurcation
3:00-4:00pm Pranay Goel: Introduction to XPP
Tuesday 8/3
9:00-10:00am Tutorial 3:
James Sneyd: Calcium physiology - PPT
10:00-10:30am Coffee Break
10:30-11:30am Tutorial 4
James Sneyd: Cardiac electrical physiology - PPT
11:30-1:30pm Lunch
1:30-2:00pm Martin Wechselberger: Introduction to Dynamical Systems (continued)
2:00-3:00pm Pranay Goel: XPP (continued)
3:00-3:30pm Coffee Break
3:30-5:30pm Project leaders describe their projects
Wednesday 8/4
9:00am Participants write their preferred projects
10:00am Teams are selected and begin work, guided by their project leaders
Thursday 8/5
9:00-10:00am Gustavo Leone: Cellular Differentiation and Cancer: PPT1
Friday 8/6
9:00-10:00am Gustavo Leone: Cellular Differentiation and Cancer: PPT2

Week 2

Tuesday 8/10
1:00-2:00pm Andrea Doseff: Apoptosis I
Wednesday 8/11
1:00-2:00pm Andrea Doseff: Apoptosis II
2:00-4:00pm Andrea Doseff: Lab
Thursday 8/12
1:00-2:00pm Berl Oakley: Gamma-tubulin functions in microtubule nucleation and cell cycle regulation
2:00pm Berl Oakley: Lab
Friday 8/13
4:00pm Gustavo Leone: Lab

 

 

 

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