Direct infusion in brain tissue: from start to finish

Raghu Raghavan
Applied Mathematics & Statistics, and Scientific Computation, University of Maryland

(February 5, 2003 4:30 PM - 5:30 PM)

Direct infusion in brain tissue: from start to finish

Abstract

Intra-parenchymal (i.e. directly into tissue) injection and transport of drugs and other agents to treat tumors and neurodegenerative diseases are being studied both theoretically and experimentally. The talk is divided into three parts. In the first, we discuss the phenomena that occur, and how to observe them principally via magnetic resonance imaging (MRI). In the second part, we review the status of the initial experiments we have undertaken in checking the predictions. Finally, we discuss how we model the phenomena, obtain the input parameters needed for the calculation, and solve the resulting equations.

 

References:

Physical modeling in biomedical computing: a research agenda, Raghu Raghavan, Center for Information-enhanced Medicine (Ciemed) Internal Report, 22 pages, unpublished, July 1994, http://www.iemed.com/Aboutus/people/raghu/presentations/PM.pdf

A continuum-mechanical model for cortical growth, Raghu Raghavan, Wayne Lawton, S.R.Ranjan and R.R. Viswanathan, Journal of Theoretical Biology, Vol. 187, pp. 285-296, 1997

Form from growth: a mechanical model for cortical development and its control, R. Raghavan, W. Lawton, S.R.Ranjan and R.R Viswanathan, Ciemed Internal Report, 9 pages, unpublished, April 1997

Corticography, Jacobi fields, and symmetries. R. Raghavan