The benefit of ion channel clustering for intracellular calcium signaling
Mathematical Biosciences Institute, The Ohio State University
(October 22, 2002 4:30 PM - 5:30 PM)
Ion channels and receptors in the cell membranes and internal membranes are often distributed in discrete clusters. One particularly well studied example is the distribution of inositol 1,4,5-triphosphate receptors in the plasma membrane that controls the flux of Ca2+ from the endoplasmic reticulum into the cytosol. By using mathematical modeling, we show that channel clustering can enhance the cell's Ca2+ signaling capability.
Furthermore, we predict optimal signaling cellular capability at cluster sizes and distances that agree with experimentally found values in Xenopus oocyte.