The benefit of ion channel clustering for intracellular calcium signaling

Peter Jung
Mathematical Biosciences Institute, The Ohio State University

(October 22, 2002 4:30 PM - 5:30 PM)

The benefit of ion channel clustering for intracellular calcium signaling

Abstract

Ion channels and receptors in the cell membranes and internal membranes are often distributed in discrete clusters. One particularly well studied example is the distribution of inositol 1,4,5-triphosphate receptors in the plasma membrane that controls the flux of Ca2+ from the endoplasmic reticulum into the cytosol. By using mathematical modeling, we show that channel clustering can enhance the cell's Ca2+ signaling capability.

 

Furthermore, we predict optimal signaling cellular capability at cluster sizes and distances that agree with experimentally found values in Xenopus oocyte.