A model for ion channel-regulated steroid hormone secretion

John Enyeart
Department of Neuroscience, The Ohio State University

(June 5, 2003 11:00 AM - 12:00 PM)

A model for ion channel-regulated steroid hormone secretion

Abstract

Adrenocortical cells secrete corticosteroids in response to ACTH released from the pituitary. Although adrenocortical cells lack Na+-dependent action potentials, the hallmark of excitable cells, cortisol secretion depends on depolarization-dependent Ca2+ entry through voltage-gated Ca2+ channels. A model is presented for cortisol secretion which depends on the three specific ion channels present in these cells. The model proposes a novel role for T-type Ca2+ channels.