Cerebellar structure, function and development: Opportunities for mathematical modeling

Andrej Rotter
Department of Pharmacology, The Ohio State University

(April 24, 2003 10:00 AM - 11:00 AM)

Cerebellar structure, function and development: Opportunities for mathematical modeling

Abstract

The cerebellum is a region of the central nervous system responsible for the coordination of complex motor movements. It consists of bilaterally symmetrical nuclei surrounded by a highly convoluted cortex. Numerous anatomical, physiological and biochemical studies have resulted in a detailed description of its cellular and molecular components, circuitry and sequence of developmental events. Nevertheless, despite the wealth of descriptive data, our understanding of the rules and relationships leading to the formation of the cerebellum and to the acquisition of its functional properties is lagging behind. In this presentation the current state of our knowledge concerning the cerebellum will be outlined and potential opportunities for mathematical modeling will be suggested.