Semi-mechanistic Modeling: Simplifying Complex Fermentation Microbiology
Mathematical Biosciences Institute, The Ohio State University
(October 2, 2002 12:30 PM - 1:30 PM)
Microbial fermentations, no matter whether they take place in "defined'' growth media or out in nature, occur in complex dynamic environments. The purpose of this talk will be to discuss a predictive modeling approach which handles this complexity while maintaining a mathematically tractable modeling framework. During this talk, the semi-mechanistic approach will be introduced by a few examples. Some basic fermentation microbiology will be provided and the approach will be applied to the study of acid tolerance in lactic acid bacteria growing in a complex medium. The work presented here may have application to other areas of research where dynamic alterations in chemical buffering are important.