Semi-mechanistic Modeling: Simplifying Complex Fermentation Microbiology

Daniel Dougherty
Mathematical Biosciences Institute, The Ohio State University

(October 2, 2002 12:30 PM - 1:30 PM)

Semi-mechanistic Modeling: Simplifying Complex Fermentation Microbiology

Abstract

Microbial fermentations, no matter whether they take place in "defined'' growth media or out in nature, occur in complex dynamic environments. The purpose of this talk will be to discuss a predictive modeling approach which handles this complexity while maintaining a mathematically tractable modeling framework. During this talk, the semi-mechanistic approach will be introduced by a few examples. Some basic fermentation microbiology will be provided and the approach will be applied to the study of acid tolerance in lactic acid bacteria growing in a complex medium. The work presented here may have application to other areas of research where dynamic alterations in chemical buffering are important.