Modulation of calcium oscillations by membrane currents

James Sneyd
Mathematics, The University of Auckland

(October 7, 2003 3:00 PM - 4:30 PM)

Modulation of calcium oscillations by membrane currents

Abstract

I'll begin with a brief discussion of the physiology of intracellular calcium signalling, and then present a model of calcium oscillations in secretory epithelial cells. I'll show how we used the model to address one particular controversy in the field, that of how calcium oscillations are affected by membrane calcium transport. I'll briefly describe how we used the model to make a number of predictions, and the experiments we did to test the predictions.