Viral optimisation within and between hosts

Dan Coombs
Department of Mathematics, University of British Columbia

(June 10, 2004 11:00 AM - 12:00 PM)

Viral optimisation within and between hosts

Abstract

Natural selection acts on viruses at a variety of levels: within cells, within hosts, and between hosts. We examine how viruses can optimise their behavior within a host under pressure from the immune system, and how this optimal within-host behavior may not be ideal from the point of view of transmission between hosts. This is a preliminary presentation of ongoing work with Michael Gilchrist (University of Tennessee) and Alan Perelson (LANL).