The Excitability of Adrenal Cortical Cells
Mathematical Biosciences Institute, The Ohio State University
(April 29, 2004 11:30 AM - 12:30 PM)
Adrenal Zona Fasciculata (AZF) cells release the hormone Cortisol in conditions of physical or psychological stress. Cortisol release is governed by the action of ion channels expressed in the AZF cells. Using the method of patch clamp, the ion channels expressed in bovine AZF cells were analyzed. Modeling of these ion channels will involve fitting mathematical equations that describe the empirical data. Creating a mathematical model that mimics the behavior of these ion channels will provide a unique understanding of the process of cortisol release and will help in predicting the possibility of membrane excitability of the AZF cells.