Alignment and Annotation of the Drosophila Genomes
Lior Pachter (Department of Mathematics, University of California, Berkeley)
(April 14, 2006 2:30 PM - 3:30 PM)
The Drosophila Genome Project is a large scale research effort whose aim is to sequence, compare and contrast 12 Drosophila genomes with the goal of significantly advancing comparative genomics methods. We will provide an overview of our recent work on annotation and alignment of the genomes, which focuses on the related problems of transposable element identification, gene finding and multiple sequence alignment. In particular, we emphasize the importance of robust alignment methods, and their relevance for identifying functional elements in genomes. A key concept is the alignment polytope, which will be explained and illustrated.