A systems biology approach to iron metabolism in cancer cells

Julia Chifman
MBI - Postdoc, The Ohio State University

(November 4, 2010 10:30 AM - 11:30 AM)

A systems biology approach to iron metabolism in cancer cells

Abstract

Computational systems biology has brought many new insights to cancer biology through the quantitative analysis of molecular networks. Our goal is to apply a systems biology approach to the understanding of intracellular iron metabolism in normal breast epithelium and the changes the network undergoes as cells transition to malignancy. This talk will describe part of a complex cellular iron network that consists of multiple feedback loops as well as a mathematical model intended to help shed light on key regulatory nodes of iron metabolism dynamics.