Mathematical Models May Lead to Better Treatment of Chronic Wounds

Avner Friedman
Department of Mathematics, The Ohio State University

(October 12, 2009 2:30 PM - 3:30 PM)

Mathematical Models May Lead to Better Treatment of Chronic Wounds

Abstract

Chronic wound healing is a staggering public health problem worldwide. It affects 6.5 million individuals in the U.S., including 1.3 million to 3 million having pressure ulcers (bedsores). As many as 10-15% of the 20 million indiviuals with diabetes in the U.S. are at risk of developing chronic ulcers. Ischemia, caused primarily by peripheral artery diseases, represents a major complicating factor in cutaneous wound healing. In this talk I will explain the wound healing process, which involves interactions among different types of cells and the extracellular matrix. I will describe pre-clinical experiments with ischemic wounds carried out in the Comprehensive Wound Center at OSU, and will present recent mathematical modeling results in a joint work with Chuan Xue and Chandan Sen