Modeling Feedback Regulation in the Human Hypothalamic-Pituitary-Thyroid Axis
Marisa Eisenberg (MBI - Postdoc, The Ohio State University)
(October 29, 2009 10:30 AM - 11:18 AM)
Thyroid hormone regulation is a classic example of biological feedback control, and thyroid disorders such as hypothyroidism affect more than 300 million people worldwide. We developed a physiologically based, ordinary differential equation model of the human hypothalamic-pituitary-thyroid axis, in order to address several clinical applications. The model is broken into two major components-- the thyroid and brain submodels, each quantified from human clinical data. We combined these two submodels to form a complete closed loop model, which we validated using additional independent clinical data. Using the closed-loop model, we address several applications in replacement thyroid hormone (L-T4) bioequivalence (equivalence between different brands/preparations of L-T4), circadian rhythms, and thyroid cancer.