A model of drug resistance with infection by health care workers

Najat Ziyadi
MBI - Long Term Visitor, The Ohio State University

(December 10, 2009 10:30 AM - 11:18 AM)

A model of drug resistance with infection by health care workers


Antibiotic resistant organisms (ARO) pose an increasing serious threat in hospitals. Factors which contribute to the spread of ARO in hospitals are poor immune system of most patients, close living quarters, and contact with health care workers (HCWs). One of the most life threatening ARO is methicillin-resistant staphylococcus aureus (MRSA).

In this talk, we will introduce a new mathematical model which focuses on the evolution of two MRSA bacterial strains: drug- resistant and non-drug resistant within population of patients and HCWs in a single hospital. We will introduce two important quantities: the threshold at which time the drug treatment is administered to patients, and time duration of drug-treatment. We will investigate the role of the amount, threshold and time duration of drug treatment on reducing the non-resistant bacteria in patients.

Simulations of the model show that as the amount of drug given to the patient is increased the drug-resistant bacteria significantly decreases, and as the treatment period is increased from one week to two weeks, the drug-resistant bacteria also decreases. Furthermore, we will demonstrate that the choice of the threshold has little influence on the outcome level of drug-resistant bacteria.