Systems Biology of Cell Signaling -- Spatial Dynamics

Ching-Shan Chou
Mathematics, The Ohio State University

(May 6, 2010 11:30 AM - 12:18 PM)

Systems Biology of Cell Signaling -- Spatial Dynamics

Abstract

Budding yeast "Saccharomyces cerevisiae" is a model system for studying cell polarization, a fundamental symmetry breaking process underlying cell physiology.In this talk, I will introduce mathematical models for the establishment and maintenance of yeast cell polarization induced by mating pheromone. Simulation results including cell morphological changes will be presented and compared to experimental data. Roles of cell membrane dynamics such as endocytosis, exocytosis and the roles the microdomains on cell membrane (lipid raft) will also be discussed.