Phylogenetic Path to Event (PhyloPTE)

Sam Handelman
Pharmacology, College of Medicine and Public Health, The Ohio State University

(May 19, 2011 10:30 AM - 11:30 AM)

Phylogenetic Path to Event (PhyloPTE)

Abstract

Several methods have been proposed for correlating genomic sequence patterns directly with phenotypes of similar organisms. However, the evolutionary relationships between organisms lead to non-independence among the sequences. A phylogenetic tree reconstruction uncovers sibling lineages where the phenotypes first start to differentiate, and, conditional on this tree, PhyloPTE adopts an additive hazard model to identify likely mutational paths along the tree as the phenotypes fully develop.