Cardiac restitution and alternans dynamics

Shu Dai
MBI - Postdoc, The Ohio State University

(December 1, 2011 10:30 AM - 11:30 AM)

Cardiac restitution and alternans dynamics

Abstract

Alternans, a long-short alternation of cardiac action potential durations, emerges as a period-doubling bifurcation under rapid pacing. Detecting alternans or bifurcation of the cardiac restitution has been a major task in prevent heart disease. We developed a new stochastic protocol and a regression method to approximate the full dynamics in a time interval. We also discuss the propagation of alternans in 1D cardiac fiber.