Feedback Regulation and Spatial Control of Multistage Cell Lineages

Jon Lo
Mathematical Biosciences Institute, The Ohio State University

(January 26, 2012 10:30 AM - 11:30 AM)

Feedback Regulation and Spatial Control of Multistage Cell Lineages

Abstract

In this study, we use multi-stage cell lineages model, which include stem cell and multiple progenitor cell stages, to study how feedback regulation from different growth controls homeostasis of tissue growth and generation of a robust spatial stratification. ODE and PDE models have been presented for the multi-stage cell lineages. Our analysis shows how negative feedbacks enhance the stability of steady states and inter-regulation among different growth factors are responsible for developing spatial stratification. We also showed that the feedback on cell cycle from the growth factor is important for forming temporary "stem cell niche" during the development of the tissue.