PhyloPTE/Peacefield - Phylogenetic Reconstruction used to improve the power of genome wide association studies (GWAS)

Sam Handelman
Pharmacology, College of Medicine and Public Health, The Ohio State University

(March 15, 2012 10:30 AM - 11:30 AM)

PhyloPTE/Peacefield - Phylogenetic Reconstruction used to improve the power of genome wide association studies (GWAS)

Abstract

PhyloPTE/P (Phylogeny with Path to Event, in People) is a method to bridge the gap between large, gene sequencing based (and, in the near future, other *omic based) studies and phylogenetically-driven approaches developed in other fields, for example epistatic-effect detection using comparison of phylogenetic tree reconstructions for different genes. PhyloPTE/P should be of interest to a wide audience of investigators, including those in biomedical informatics or medical genomics, as well as those in systems biology or evolutionary biology, and serve as a software platform to foster collaboration between the two areas.