Molecular-motor based transport: how does it function, and what can theoretical modeling contribute to understanding it?

Steven Gross
Developmental and Cell Biology, University of California, Irvine

(November 18, 2013 3:00 PM - 3:50 PM)

Molecular-motor based transport: how does it function, and what can theoretical modeling contribute to understanding it?

Abstract

Cells are highly ordered, and much of this organization is controlled by active molecular-motor based transport. At the single-molecule level, biophysical studies have been very effective at determining how motors work. However, in cells, motors do not function by themselves, but rather, act in groups. How these groups function is less well understood. In this talk I will discuss our experimental evidence underlying the statement that motors function in groups, and will then discuss how modeling can be used as a key tool to understand both how groups of motors function, and also which aspects of their single-molecule properties are particularly important for controlling this ensemble function.