Mitochondrial Modulation of Intracellular Ca2+ Signaling

Chris Fall
Department of Anatomy and Cell Biology, University of Illinois

(January 11, 2007 10:30 AM - 11:30 AM)

Mitochondrial Modulation of Intracellular Ca2+ Signaling

Abstract

It is not widely appreciated that mitochondria are important participants in intracellular Ca2+ signaling. In cells expressing highly dynamic Ca2+ signaling behavior, mitochondria can shape the spatiotemporal patterns. In addition, mitochondria have been shown to act as an independent network of oscillators. These phenomena are gaining attention as evidence points to mitochondrial dysfunction as a potential factor in diseases such as neurodegeneration. I will review the work of others and present some of our own results regarding mitochondria and Ca2+ signaling. In particular I will discuss efforts to model dynamic phenomena involving mitochondria, and I will sketch out areas which might benefit from additional theoretical attention.