Use of Mechanobiology in Tissue Engineering

Keith Gooch
Department of Biomedical Engineering, The Ohio State University

(December 1, 2006 10:30 AM - 11:30 AM)

Use of Mechanobiology in Tissue Engineering

Abstract

The goal of tissue engineering is to direct the generation and remodeling of tissues often for potential clinical applications. This talk will explore the use of mechanobiology - the study of the biological effects of mechanical forces - in tissue engineering using three examples; mechanically induced growth and remodeling of blood vessels cultured outside of the body, capillary morphogenesis in 3D substrates with various mechanical properties, and the in vitro differentiation of precursor cells to insulin producing pancreatic cells. Efforts by my laboratory and others to use mathematical modeling to better understand these systems will be noted but the focus of the talk will be the underlying biological process.