Adaptation and Control of Biofilms
Barbara Szomolay (Mathematical Biosciences Institute (MBI), The Ohio State University)
(October 12, 2006 10:30 AM - 11:30 AM)
In this talk a biofilm model with growth and detachment is discussed, hence, making the model interesting in applications. The crucial feature of our model is that cells are able to enter an adapted resistant state when challenged with antimicrobials (adaptation). The model is presented in both a qualitative and quantitative manner. Existence and uniqueness of solutions can be shown as well as the existence and non-uniqueness of steady-state solutions. Another question of interest is the effective dosing of biocide, i.e., exploring dosing strategies that could minimize the number of living cells or biofilm thickness. Constant and periodic dosing regimes were modelled numerically. One of our main results is that on and off dosing is significantly better than the other dosing types. The model contributes to a better understanding of one of the resistant mechanisms in biofilms.