Workshop 7: Stem Cells, Development, and Cancer

(April 13,2015 - April 17,2015 )

Organizers


Heiko Enderling
Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute
Thomas Hillen
Mathematical and Statistical Sciences, University of Alberta
John Lowengrub
Mathematics, University of California, Irvine

Most tissues are hierarchically organized into lineages. A lineage is a set of progenitor-progeny relationships within which progressive changes in cell character occur. Typically, lineages are traced back to a self-perpetuating stem cell (SC), and end with a postmitotic terminal cell. One of the most exciting recent developments in the field of cancer biology is the recognition that lineage progression continues to occur in tumors. In particular there is an increasing body of evidence that like normal tissues, tumor cells that have the potential for unlimited self-renewal give rise in large numbers to cells that lack this potential - the so-called cancer stem cell hypothesis. By focusing for so many years on the majority cell populations in tumors, and not on the rarer cancer stem cells (cancer initiating cells), scientists and clinicians may have missed out on opportunities to understand, diagnose and treat the processes in cancer that matter most. Further, there is increasing evidence that cell stemness may be a function of the local environment rather than being a predetermined property of a cell. What are the consequences of this plasticity in cell behavior? Other important open questions in the field include: What cell types within the normal tissues are capable of being the cells of origin for tumors? What is the relationship between normal tissue stem cells and tumor-initiating cells (e.g., cancer stem cells)? Which signaling and other regulatory networks are altered in tumors relative to the normal tissues, and how do they function within the tumor? Finally, there is growing evidence that therapies aimed at the major cell types in tumors may sometimes make things worse, by leading to an expansion in the fraction of cancer stem cells. How can this be avoided? This workshop will address these and other questions through discussions among mathematical and computational modelers and experimentalists. In particular, the strong connections between normal development, tumor growth and the use of novel treatment strategies will be discussed.

Accepted Speakers

Zvia Agur
Institute for Medical Biomathematics
David Axelrod
Department of Genetics, Rutgers University
Andreas Buttenschoen
Department of Mathematical and Statistical Sciences, University of Alberta
Helen Byrne
Centre for Mathematical Medicine and Biology, University of Nottingham
Vincenzo Capasso
ADAMSS, Università degli Studi di Milano and "Gregorio Millan" Institute Escuela Politecnica Superior Universidad Carlos III de Madrid
Dirk Drasdo
Bioinformatics, Physical and Mathematical Biology, Institut National de Recherche en Informatique Automatique (INRIA)
Avner Friedman
Department of Mathematics, The Ohio State University
Ryan Gao
Inria Team Dracula, Inria Center Grenoble Rhone-Alpes
Philip Hahnfeldt
Center of Cancer Systems Biology, Tufts University
Leonid Hanin
Department of Mathematics, Idaho State University
Anita Hjelmeland
Cell, Developmental and Integrative Biology, University of Alabama at Birmingham
Yangjin Kim
Department of Mathematics, Konkuk University
Marek Kimmel
Department of Statistics, Rice University
Natalia Komarova
Department of Mathematics, University of California, Irvine
Paul Macklin
Center for Applied Molecular Medicine, University of Southern California
Anna Marciniak-Czochra
Institute of Applied Mathematics, Ruprecht-Karls-Universit""at Heidelberg
Kevin Painter
Department of Mathematics, Heriot-Watt University
Alexander Pearson
Hematology and Medical Oncology, University of Michigan
Jan Poleszczuk
Lynne-Marie Postovit
Oncology, University of Alberta
Sotiris Prokopiou
Integrated Mathematical Oncology, Cancer Center
Jeremy Rich
Stem Cell Biology and Regenerative Medicine, Cleveland Clinic
Ignacio Rodriguez-Brenes
Mathematics, University of California, Irvine
Andrea Sottoriva
Centre for Evolution and Cancer, The Institute of Cancer Research
Christina Surulescu
Mathematics, Felix-Klein-Zentrum für Mathematik, TU Kaiserslautern
Kristin Swanson
Department of Pathology, University of Washington
Jose Ignacio Tello
Department of Applied Mathematics, Universidad Complutense de Madrid
Vitaly Volpert
Mathematics and applications, CNRS
Monday, April 13, 2015
Time Session
Tuesday, April 14, 2015
Time Session
Wednesday, April 15, 2015
Time Session
Thursday, April 16, 2015
Time Session
Friday, April 17, 2015
Time Session
Name Email Affiliation
Agur, Zvia agur@imbm.org Institute for Medical Biomathematics
Axelrod, David axelrod@biology.rutgers.edu Department of Genetics, Rutgers University
Buttenschoen, Andreas andreas.buttenschoen@ualberta.ca Department of Mathematical and Statistical Sciences, University of Alberta
Byrne, Helen byrneh@maths.ox.ac.uk Centre for Mathematical Medicine and Biology, University of Nottingham
Capasso, Vincenzo vincenzo.capasso@unimi.it ADAMSS, Università degli Studi di Milano and "Gregorio Millan" Institute Escuela Politecnica Superior Universidad Carlos III de Madrid
Drasdo, Dirk dirk.drasdo@inria.fr Bioinformatics, Physical and Mathematical Biology, Institut National de Recherche en Informatique Automatique (INRIA)
Enderling, Heiko heiko.enderling@moffitt.org Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute
Friedman, Avner afriedman@math.ohio-state.edu Department of Mathematics, The Ohio State University
Gao, Xuefeng ryan.gaoim@gmail.com Inria Team Dracula, Inria Center Grenoble Rhone-Alpes
Hahnfeldt, Philip philip.hahnfeldt@tufts.edu Center of Cancer Systems Biology, Tufts University
Hanin, Leonid hanin@isu.edu Department of Mathematics, Idaho State University
Hillen, Thomas thillen@ualberta.ca Mathematical and Statistical Sciences, University of Alberta
Hjelmeland, Anita hjelmea@uab.edu Cell, Developmental and Integrative Biology, University of Alabama at Birmingham
Kim, Yangjin ahyouhappy@konkuk.ac.kr Department of Mathematics, Konkuk University
Kimmel, Marek kimmel@rice.edu Department of Statistics, Rice University
Komarova, Natalia komarova@uci.edu Department of Mathematics, University of California, Irvine
Macklin, Paul Paul.Macklin@usc.edu Center for Applied Molecular Medicine, University of Southern California
Marciniak-Czochra, Anna Anna.Marciniak@iwr.uni-heidelberg.de Institute of Applied Mathematics, Ruprecht-Karls-Universit""at Heidelberg
Painter, Kevin painter@ma.hw.ac.uk Department of Mathematics, Heriot-Watt University
Pearson, Alexander pearsona@med.umich.edu Hematology and Medical Oncology, University of Michigan
Poleszczuk, Jan j.poleszczuk@mimuw.edu.pl
Postovit, Lynne-Marie postovit@ualberta.ca Oncology, University of Alberta
Prokopiou, Sotiris sotirisprokopiou1@gmail.com Integrated Mathematical Oncology, Cancer Center
Rich, Jeremy richj@ccf.org Stem Cell Biology and Regenerative Medicine, Cleveland Clinic
Rodriguez-Brenes, Ignacio iarodrig@uci.edu Mathematics, University of California, Irvine
Sishc, Brock Brock.sishc@utsouthwestern.edu Radiation Oncology, UT Southwestern Medical Center
Sottoriva, Andrea sottoriv@usc.edu Centre for Evolution and Cancer, The Institute of Cancer Research
Surulescu, Christina surulescu@mathematik.uni-kl.de Mathematics, Felix-Klein-Zentrum für Mathematik, TU Kaiserslautern
Swanson, Kristin kristin.swanson@northwestern.edu Department of Pathology, University of Washington
Tello, Jose Ignacio jtello@eui.upm.es Department of Applied Mathematics, Universidad Complutense de Madrid
Volpert, Vitaly volpert@math.univ-lyon1.fr Mathematics and applications, CNRS