Similarity and homology in proteins.
Nick Grishin (Southwestern Medical Center, University of Texas)
(October 6, 2014 3:00 PM - 3:50 PM)
Evolutionary relationships (i.e., homology) detected between proteins helps predict their properties such as spatial structures and functions. Homology is frequently obscured by sequence divergence, spatial structure changes and resemblance between unrelated 3D structures. Computational approaches to the analysis of distant homologs and their discrimination from proteins with fortuitous similarities will be discussed and examples of how this theoretical and bioinformatics work facilitates experimental discoveries will be given.