Modeling and Analyzing Cortical Folding Patterns of the Human Brain in Development, Aging, and Disease

Monica Hurdal
Department of Mathematics, Florida State University

(March 11, 2014 9:10 AM - 10:00 AM)

Modeling and Analyzing Cortical Folding Patterns of the Human Brain in Development, Aging, and Disease

Abstract

The folding pattern of the human brain has many ridges (gyri) and valleys (sulci), making it difficult to visualize and analyze. The development of these folding patterns is not fully understood and there is debate in the biological and neuroscientific communities as to why folds develop in a particular location. Additionally, there are many diseases involving the folding the patterns of the brain that occur in early development and causes of these diseases are not understood. I will discuss some mathematical and computational models we have developed using a prolate spheroid domain to gain insight into cortical folding pattern formation. I will also discuss how conformal mapping and topology can assist with the study and analysis of diseases in the human brain.