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Gagan Agrawal
agrawal@cis.ohio-state.edu
My interests are mainly in high-end computing and data mining.
Of particular focus are statistical and other techniques for
analyzing biological datasets including those related to gene
sequences, gene expression, and protein folding. Another area
is tools for high-end computing, including middleware, runtime,
compiler, and algorithmic techniques for solving large scale
computational and data-intensive problems.
Michael Beattie
beattie.2@osu.edu
My research areas include neural development, plasticity and
regeneration, spinal cord injury and recovery of function,
cellular basis for neural growth and cell death, spinal cord
reflexes, neuroanatomy, neurophysiology, and behavioral neuroscience.
Georgia Bishop
bishop.9@osu.edu
My research areas are anatomical, pharmacological, and physiological
organization of the cerebellum including connections from
the brainstem.
Anthony Brown
brown.2302@osu.edu
Axonal transport is the mechanism by which proteins and membranous
organelles move along nerve fibers from their site of synthesis
in the nerve cell body. This movement is essential for the
growth and survival of axons, and it continues throughout
the life of the neuron. I am interested in using mathematical
modeling to test specific hypotheses concerning the mechanism
of axonal transport.
John Buford
buford.5@osu.edu
In the primate, the organization of systems for control of
movement is remarkably similar to that of the human. From
analysis of signals from neurons in multiple locations within
the brain, the communication and coordination within neural
networks is being deciphered. In my laboratory, students record
for neurons in awake, behaving primates. Opportunities exist
for neural network modeling among components of these circuits
and analysis of neural influences within the circuits. Quantification
of the strengths of connections between the brain and the
muscles during movement is also required.
Ralf Bundschuh
bundschuh@mps.ohio-state.edu
Research in the Bundschuh group revolves around
the physical properties and interactions of
biopolymers (largely nucleic acids but also some
proteins) and statistical as well as algorithmic
questions in biological sequence analysis. Current
research includes projects on the thermodynamics
and kinetics of RNA secondary structure, RNA editing,
and protein sequence database searches.
Umit Catalyurek
catalyurek.1@osu.edu
I have been working on runtime systems for data management
and manipulation of very large databases, and hypergraph partitioning
methods, with a particular focus on parallel computing applications.
My current research focuses on runtime optimizations and systems
software for efficient storage and processing of very large
scientific datasets on disk-based storage clusters and in
the grid environment.
Ramana Davuluri
Davuluri-1@medctr.osu.edu
In recent years, Bioinformatics and Computational Biology
tools have proven to be invaluable in biomedical research.
The major goal of my laboratory is to develop statistically
rigorous computational tools that will accelerate research
in human cancer genetics and eventually translate into the
clinical setting. My group is currently working on: (i) development
of computational tools to annotate transcriptional regulatory
regions in mammalian genomes; (ii) development of pattern
recognition methods and statistical models to identity transcription
factor binding sites, model transcriptional modules, and networks
in hematopoiesis cell lineages; and (iii) development of robust
databases and visualization tools for genomic data and annotations.
For more information about my lab, please visit http://bioinformatics.med.ohio-state.edu.
John Enyeart
enyeart.1@osu.edu
My research is focused on ion channels in secretory cells,
and the exploration of their role in regulating hormone secretion
and gene expression. I am interested in the possibility that
electrically-coupled endocrine cells function as synchronized
coupled oscillators, wherein hormone secretion is tightly
linked to Ca2+ influx through synchronized oscillating
membrane potentials. Secretion may be optimized in glandular
cells through modulation of waveform amplitude and frequency.
Mathematical models of electrical activity in cellular networks
can be tested using electrophysiological methods, including
patch clamp.
Erich Grotewold
grotewold.1@osu.edu
One of the interests of my lab is to establish the architecture of regulatory networks in higher eukaryotes, using plants (Arabidopsis and maize) as models. We utilize combinations of genome-wide RNA profiling (microarrays) coupled with chromatin immunoprecipitation (ChIP) and genome-widel location analyses (ChIP on chip) to determine where transcription factors bind in the genome and what genes they directly control. This information is then used to populate our databases on plant transcription factors and cis-regulatory elements, with the goal to visualize regulatory motifs. We also investigate how transcription factors with very similar DNA-binding domains acquire regulatory specificity, primarily by interacting with other cofactors.
Sissy Meihua Jhiang
jhiang.1@osu.edu
My current research interests are in two areas: (a) characterization
of signaling pathways induced by the activation of RET receptor
tyrosine kinases in human cancers and clinical applications
of the acquired information to improve medical care for patients
with cancers of MEN 2 inherited cancer syndromes or papillary
thyroid carcinoma; and (b) characterization and regulation
of Na+/I- symporter(NIS) and its clinical applications in
noninvasive tumor imaging in vivo and radioiodine therapy
for human cancers by induced endogenous NIS expression or
by NIS gene transfer to facilitate exogenous NIS expression.
Tahsin Kurc
kurc.1@osu.edu
My research interests include data-intensive computing, where
I have developed techniques, systems software, and middleware
tools to provide support for storage, data management, and
manipulation of very large scientific datasets. In particular,
in high-performance computing area, I am interested in domain
decomposition techniques for efficient distribution of data
and computation in scientific and engineering applications
on distributed-memory machines, and the application of parallel
computing in scientific visualization.
Jeff Kuret
kuret.3@osu.edu
This laboratory studies molecular mechanisms underlying Alzheimer's
disease pathogenesis. One aspect of our program focuses on
the discovery of small molecule ligands that bind and also
block the formation of neurofibrillary lesions, which are
comprised of proteinaceous filaments. We are interested in
applying mathematical modeling in conjunction with inhibition
kinetic data to clarify the mechanism of action of these ligands.
Stuart C. Mangel
mangel.1@osu.edu
We use the vertebrate retina, which is part of the brain,
as a model system for understanding brain function due to
its easy accessibility and well-characterized inputs. My laboratory
is currently pursuing two research objectives using electrophysiological,
neurochemical, anatomical, and computational techniques. First,
we are studying how a circadian (24-hour) clock, a type of
biological oscillator, in the retina modulates cellular processes
and chemical and electrical synaptic transmission to control
adaptive state so that the retina can respond to visual images
in both the day and night during which the ambient or background
illumination changes by approximately 8 orders of magnitude.
Second, we are studying the cellular, subcellular, and neural
network mechanisms that underlie the computation of the direction
of image motion in the retina. The neural coding of the direction
of stimulus motion, which is a classic example of local neural
computation, is a common feature of the nervous system.
Karl Obrietan
obrietan.1@osu.edu
My laboratory utilizes a combination of cellular, molecular,
and behavioral approaches to examine the second messenger
signaling and transcriptional pathways that regulate biological
timing. Another area of research examines the cellular signaling
events that couple changes in cytosolic calcium to transcriptionally-dependent
forms of neuronal plasticity in the cortex and hippocampus.
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Mike Ostrowski
ostrowski.4@osu.edu
My lab has a long-standing interest in understanding how signaling
pathways elicit selective changes in gene transcription in
mammalian cells. More recently, we have become interested
in understanding interactions between signaling pathways locating
the different cell types involved in these complex biological
processes of cancer cell progression and normal cellular differentiation.
For example, a breast tumor is composed not only of the epithelial-cell
derived tumor cell, but also stromal cells, endothelial cells,
and immune cells including macrophages, B-cells and T-cells.
It is the interaction of these cell types through complex
signaling networks that are likely to be important for tumor
cell progression and metastasis and not just the action of
individual signaling pathways within the epithelial tumor
cell.
John M. Robinson
robinson.21@osu.edu
My laboratory studies intracellular trafficking of membranes
and certain protein molecules(e.g., IgG) in cells and tissues.
We are particularly interested in specialized microdomains
of the plasma membrane known as caveolae. Caveolae are thought
to be enriched in certain lipids (i.e., sphingolipids and
cholesterol) and a number of proteins associated with signal
transduction events including caveolin. In addition, we are
interested in the cytoskeleton of cells and how these polymeric
supermolecular assemblies regulate the intracellular movements
as well as motility of cells.
Andrej Rotter
rotter.1@osu.edu
My research areas include: molecular neuroanatomy of developing
cerebellar circuits and synapses and developmental regulation
of neurotransmission involving glutamate and GABA/benzodiazepine
receptors. My more recent interest is in genomics.
Wolfgang Sadee
sadee.1@osu.edu
The effective application of genomic information to drug discovery
and therapy promises a revolution in the treatment and prevention
of disease. Current databases – on gene expression, proteomics,
polymorphisms, tissue banks, drug effects and toxicities,
and clinical outcomes – expand exponentially. Yet, the
enormous complexity of the data impedes our ability to extract
key elements relevant to therapy. Our challenge is to develop
a mathematical/statistical approach to the design and interpretation
of complex data sets from laboratory experiments and clinical
trials.
Joel Saltz
saltz.3@osu.edu
I am interested in the applications of large scale computing
to areas in computational biology, such as cardiac conduction,
blood flow, neural models, and cellular modeling.
Martin Sarter
sarter.2@osu.edu
My research areas are: cognitive functions of cortical transmitter
systems, specifically cortical acetylcholine; neurotransmitter
interactions in the basal forebrain and attention; neuropharmacological
and cognitive foundations of drug-induced cognition enhancement
and the treatment of age-related dementias; neuronal mechanisms
mediating psychotic cognition; and neuronal mechanisms mediating
the cognitive processes that contribute to the development
of drug addiction. My current research includes experiments
on the mediation of attentional functions (sustained and divided
attention) by afferent circuits of basal forebrain corticopetal
cholinergic projections, and on the role of these circuits
in the manifestation of drug addiction, symptoms of schizophrenia,
as well as in other neuropsychiatric disorders.
Dale D. Vandre
vandre.1@osu.edu
Research in Dr. Vandre's laboratory examines posttranslational
modification of cytoskeletal proteins involved in regulating
cell cycle progression, cell differentiation, and degeneration.
Current studies include development of proteomic, RNS interference,
and immunocytochemical approaches to examine the functional
properties of cytoskeletal proteins and the mechanisms of
action for new cancer chemotherapeutic agents.
Mike Zhu
zhu.55@osu.edu
My lab focuses on the structure and function relationship
of cation channels. Some of these channels mediate calcium
influx following the stimulation of phospholipase C and thus
control calcium homeostasis inside the cells. These channels
have different activation and inactivation kinetics and are
modulated by a number of cellular factors. Our challenge is
to model the changes of intracellular calcium concentrations
as functions of channel activity under different physiological
conditions. The proposed models will be tested using electrophysiological
and calcium imaging techniques.
Tom Waite
waite.1@osu.edu
Our research interests fall in the fields of evolutionary
ecology and biodiversity science. In evolutionary ecology,
we use optimality models to study decision making under cognitive
constraints, focusing on violations of rationality. We use
game theoretic and genetic algorithm models to study evolution
of cooperation among selfish agents. With colleague Kevin
Passino, we also use evolutionarily inspired models for biomimicry
in engineering. In biodiversity science, we use quantitative
methods to evaluate extinction risk and macroecological processes.
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