Upcoming Colloquia

All seminars will be held in the MBI Lecture Hall - Jennings Hall, Room 355 - unless otherwise noted.

November 10, 2014 3:00 - 3:50PM

Recent evidence suggests that, like many normal tissues, many cancers are maintained by a small population of cancer stem cells that divide indefinitely to produce more differentiated cancerous cells. Tissues, however, contain many more differentiated cells than stem cells, and mutations may cause such cells to "dedifferentiate" into a stem-like state. We  study the effects of dedifferentiation on the time to cancer onset and found that the effect of dedifferentiation depends critically on how stem cell numbers are controlled by the body. If homeostasis is very tight (due to all divisions being asymmetric), then dedifferentiation has little effect, but if homeostatic control is looser (allowing both symmetric and asymmetric divisions), then dedifferentiation can dramatically hasten cancer onset and lead to exponential growth of the cancer stem cell population. We consider both space-free and spatial versions of this process to look at effect that tissue architecture can play in this process. Our results suggest that dedifferentiation may be a very important factor in cancer and that more study of dedifferentiation and stem cell control is necessary to understand and prevent cancer onset.

TBD
November 24, 2014 3:00 - 3:50PM
Host: TBD

Abstract not submitted.

TBD
December 01, 2014 3:00 - 3:50PM
Host: Andrej Rotter

Abstract coming soon.

TBD
January 26, 2015 3:00 - 3:50PM
Host: Soledad Fernandez

Abstract not submitted.

TBD
February 23, 2015 3:00 - 3:50PM
Host: TBD

Abstract not submitted.

TBD
March 02, 2015 3:00 - 3:50PM
Host: TBD

Abstract not submitted.

TBD
March 09, 2015 3:00 - 3:50PM
Host: TBD

Abstract not submitted.

TBD
April 06, 2015 3:00 - 3:50PM
Host: TBD

Abstract not submitted.

TBD
April 20, 2015 3:00 - 3:50PM
Host: TBD

Abstract not submitted.