Upcoming Postdoc Seminars

All seminars will be held in the MBI Lecture Hall - Jennings Hall, Room 355 - unless otherwise noted.

October 23, 2014 10:20 - 11:15AM

Nuclei in the Drosophila embryo undergo 8 synchronous division cycles followed by division waves of decreasing speed that travel through the embryo until the 14th cycle. Recent advances in microscopic in vivo imaging allow us to obtain precise timing data for the 10th through 13th divisions, and these division times show remarkable synchronization across local populations. Statistical analysis indicates that these nuclei must be coordinating their cell cycles, and the syncytial nature of the Drosophila embryo suggests a chemical signaling mechanism. Comparison with earlier work further suggests that the communication has a Response / Signaling form with a positive impulse.

In 2007, Calzone et al demonstrated a numerical model of early Drosophila embryogenesis that reproduces many features of the process, but which treats the nuclei as a single mass. By adding a spatial component to the model, we show that cytoplasmic diffusion of Cyclin B and Cdk1 drives local synchrony. Including the breakdown of the nuclear envelope during mitosis reproduces the slowing division waves as well.

TBD
October 30, 2014 10:20 - 11:15AM

Abstract Not Submitted

TBD
November 13, 2014 10:20 - 11:15AM

Abstract Not Submitted

TBD
November 13, 2014 10:20 - 11:15AM

Abstract Not Submitted

TBD
November 13, 2014 10:20 - 11:15AM

Abstract Not Submitted

TBD
November 13, 2014 3:00 - 3:50PM

Abstract not submitted.

TBD
December 04, 2014 10:20 - 11:15AM

Abstract Not Submitted

TBD
December 11, 2014 10:20 - 11:15AM

Abstract Not Submitted

TBD
January 15, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
January 22, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
January 29, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
February 12, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
February 26, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
March 05, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
March 12, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
March 19, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
April 02, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
April 09, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
April 23, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
May 07, 2015 10:20 - 11:15AM

Abstract Not Submitted

TBD
May 14, 2015 10:20 - 11:15AM

Abstract Not Submitted

Upcoming Visitor Seminars

October 21, 2014 10:20 - 11:15AM

Existing mathematical models of tumor development are either discrete (cell-based) models or continuum models. Both have advantages and disadvantages; the former allows for incorporation of significant cell-level information but is computationally expensive when growth and mechanics are incorporated, whereas the latter is easy to formulate and computationally straightforward, but to date it has been difficult to accurately translate cell-level information into the continuum description. In this talk we introduce a hybrid model that retains the advantages of both the discrete and the continuum models. In this model the surface layers of a growing multicellular spheroid are described by a cell-based model, whereas the interior quiescent and necrotic zones (when present) are described by a continuum model, as is the extracellular matrix. We will discuss the theoretical foundation of the model and the computational algorithms developed to analyze it, and present numerical results for growing tumors.

TBD
October 28, 2014 10:20 - 11:15AM
Host: TBD

Abstract not submitted.

TBD
November 12, 2014 10:20 - 11:20AM
Host: TBD

Abstract not submitted.

TBD
December 02, 2014 10:20 - 11:15AM
Host: TBD

Abstract not submitted.

upcoming special seminars