Upcoming Postdoc Seminars

All seminars will be held in the MBI Lecture Hall - Jennings Hall, Room 355 - unless otherwise noted.

October 23, 2014 10:20 - 11:15AM

Nuclei in the Drosophila embryo undergo 8 synchronous division cycles followed by division waves of decreasing speed that travel through the embryo until the 14th cycle. Recent advances in microscopic in vivo imaging allow us to obtain precise timing data for the 10th through 13th divisions, and these division times show remarkable synchronization across local populations. Statistical analysis indicates that these nuclei must be coordinating their cell cycles, and the syncytial nature of the Drosophila embryo suggests a chemical signaling mechanism. Comparison with earlier work further suggests that the communication has a Response / Signaling form with a positive impulse.

In 2007, Calzone et al demonstrated a numerical model of early Drosophila embryogenesis that reproduces many features of the process, but which treats the nuclei as a single mass. By adding a spatial component to the model, we show that cytoplasmic diffusion of Cyclin B and Cdk1 drives local synchrony. Including the breakdown of the nuclear envelope during mitosis reproduces the slowing division waves as well.

October 30, 2014 10:20 - 11:15AM

In this two-part talk, I will present a model for the regulation of precipitation of calcium phosphate species in biological tissues.  Calcium is an important ion for both structural support and biochemical signaling in vertebrates. As a result, it is necessarily maintained at high concentrations in fluids - at levels whereprecipitation is favored. Yet, such precipitation, when it occurs in an uncontrolled manner, is harmful. Using concepts from classical nucleation theory, I will discuss how biological organisms can regulate this high calcium concentration.

Nucleation and crystallization problems such as this one are often studied through the use of atomic force microscopy (AFM). AFM and related techniques are associated with inverse problems of Brownian motion. In the second part of my talk, I will discuss the inverse problem of potential energy reconstruction for random walkers under non-constant diffusivity. I will present a self-contained, nonparametric, regularized method based on Bayesian inference under which a path integral is used for uncertainty quantification. Under this method, regularization parameters are determined through optimization of an eigenvalue problem for a trace-class operator.

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November 13, 2014 10:20 - 11:15AM

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November 13, 2014 10:20 - 11:15AM

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November 13, 2014 10:20 - 11:15AM

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November 13, 2014 3:00 - 3:50PM

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December 04, 2014 10:20 - 11:15AM

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December 11, 2014 10:20 - 11:15AM

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January 15, 2015 10:20 - 11:15AM

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January 22, 2015 10:20 - 11:15AM

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January 29, 2015 10:20 - 11:15AM

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February 12, 2015 10:20 - 11:15AM

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February 26, 2015 10:20 - 11:15AM

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March 05, 2015 10:20 - 11:15AM

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March 12, 2015 10:20 - 11:15AM

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March 19, 2015 10:20 - 11:15AM

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April 02, 2015 10:20 - 11:15AM

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April 09, 2015 10:20 - 11:15AM

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April 23, 2015 10:20 - 11:15AM

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May 07, 2015 10:20 - 11:15AM

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May 14, 2015 10:20 - 11:15AM

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Upcoming Visitor Seminars

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October 28, 2014 10:20 - 11:15AM
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November 12, 2014 10:20 - 11:20AM
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December 02, 2014 10:20 - 11:15AM
Host: TBD

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upcoming special seminars