Upcoming Postdoc Seminars

All seminars will be held in the MBI Lecture Hall - Jennings Hall, Room 355 - unless otherwise noted.

October 30, 2014 10:20 - 11:15AM

In this two-part talk, I will present a model for the regulation of precipitation of calcium phosphate species in biological tissues.  Calcium is an important ion for both structural support and biochemical signaling in vertebrates. As a result, it is necessarily maintained at high concentrations in fluids - at levels whereprecipitation is favored. Yet, such precipitation, when it occurs in an uncontrolled manner, is harmful. Using concepts from classical nucleation theory, I will discuss how biological organisms can regulate this high calcium concentration.

Nucleation and crystallization problems such as this one are often studied through the use of atomic force microscopy (AFM). AFM and related techniques are associated with inverse problems of Brownian motion. In the second part of my talk, I will discuss the inverse problem of potential energy reconstruction for random walkers under non-constant diffusivity. I will present a self-contained, nonparametric, regularized method based on Bayesian inference under which a path integral is used for uncertainty quantification. Under this method, regularization parameters are determined through optimization of an eigenvalue problem for a trace-class operator.

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November 13, 2014 10:20 - 11:15AM

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December 04, 2014 10:20 - 11:15AM

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December 11, 2014 10:20 - 11:15AM

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January 15, 2015 10:20 - 11:15AM

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January 22, 2015 10:20 - 11:15AM

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January 29, 2015 10:20 - 11:15AM

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February 12, 2015 10:20 - 11:15AM

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February 26, 2015 10:20 - 11:15AM

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March 05, 2015 10:20 - 11:15AM

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March 12, 2015 10:20 - 11:15AM

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March 19, 2015 10:20 - 11:15AM

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April 02, 2015 10:20 - 11:15AM

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April 09, 2015 10:20 - 11:15AM

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April 23, 2015 10:20 - 11:15AM

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May 07, 2015 10:20 - 11:15AM

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May 14, 2015 10:20 - 11:15AM

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Upcoming Visitor Seminars

November 12, 2014 10:20 - 11:15AM
Host: TBD

When radiation therapy is applied to a tumor, then inevitably, healthy tissue is exposed too. It is quite common that side effects arise or that organs fail.  The normal tissue complication probability (NTCP) is an attempt to quantify the risks of side effects. So far, NTCP models have been based on statistical outcomes. In my talk I will develop a mechanistic model for tissue complication which is based on organ-specific and patient-specific model parameters. We get a surprisingly simple formulation of the NTCP, which only requires a few, obtainable, physiological characteristics.

December 02, 2014 10:20 - 11:15AM
Host: TBD

Polynomial systems arise in a variety of applications, but there are few effective methods for solving them. Recently, several methods have been developed, providing numerical approximations to the solutions of polynomial systems. In this talk, I will introduce some of the main tools from this relatively new toolbox, collectively called numerical algebraic geometry. I will also briefly describe some ongoing applications of these methods to population genetics, chemical reaction networks, and model selection. This will be a gentle introduction, with virtually no assumptions about your knowledge of algebra, geometry, or polynomials.

upcoming special seminars