MBI Publications

MBI Publications for Matthew Bennett (2)

  • J. Kim, Z. Kilpatrick, M. Bennett and K. Josic
    Molecular mechanisms that regulate the coupled period of the mammalian circadian clock
    Biophysical JournalVol. 106 No. 9 (2014) pp. 2071–2081


  • Y. Chen, J. Kim, A. Hirning, K. Josi? and M. Bennett
    Emergent genetic oscillations in a synthetic microbial consortium
    ScienceVol. 349 No. 6251 (2015) pp. 986-989


    A challenge of synthetic biology is the creation of cooperative microbial systems that exhibit population-level behaviors. Such systems use cellular signaling mechanisms to regulate gene expression across multiple cell types. We describe the construction of a synthetic microbial consortium consisting of two distinct cell types€”an €œactivator€? strain and a €œrepressor€? strain. These strains produced two orthogonal cell-signaling molecules that regulate gene expression within a synthetic circuit spanning both strains. The two strains generated emergent, population-level oscillations only when cultured together. Certain network topologies of the two-strain circuit were better at maintaining robust oscillations than others. The ability to program population-level dynamics through the genetic engineering of multiple cooperative strains points the way toward engineering complex synthetic tissues and organs with multiple cell types.

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