MBI Publications

MBI Publications for Chandan Sen (5)

  • J. Verducci, V. Melfi, S. Lin, Z. Wang, S. Roy and C. Sen
    Microarray Analysis of Gene Expression: Considerations in Data Mining and Statistical Treatment
    Physiol. GenomicsVol. 25 (2006) pp. 355-363

    Abstract

  • R. Zhao, A. Friedman, R. Schugart and C. Sen
    Wound angiogenesis as a function of tissue oxygen tension - a mathematical model
    PNAS USAVol. 105 (2008) pp. 2628-2633

    Abstract

  • C. Xue, A. Friedman and C. Sen
    A mathematical model of ischemic cutaneous wounds
    PNASVol. 106 No. 39 (2009) pp. 16782-16787

    Abstract

    Chronic wounds represent a major public health problem affecting 6.5 million people in the United States. Ischemia, primarily caused by peripheral artery diseases, represents a major complicating factor in cutaneous wound healing. In this work, we sought to develop a mathematical model of ischemic dermal wounds. The model consists of a coupled system of partial differential equations in the partially healed region, with the wound boundary as a free boundary. The extracellular matrix (ECM) is assumed to be viscoelastic, and the free boundary moves with the velocity of the ECM at the boundary. The model equations involve the concentration of oxygen, PDGF and VEGF, the densities of macrophages, fibroblasts, capillary tips and sprouts, and the density and velocity of the ECM. Simulations of the model demonstrate how ischemic conditions may limit macrophage recruitment to the wound-site and impair wound closure. The results are in general agreement with experimental findings.
  • C. Xue, C. Chou, C. Kao, C. Sen and A. Friedman
    Propagation of Cutaneous Thermal Injury: A Mathematical Model
    Wound Repair and RegenVol. 20 No. 1 (2012) pp. 114-122

    Abstract

  • C. Xue, C. Chou, C. Kao, C. Sen and A. Friedman
    Propagation of Cutaneous Thermal Injury: A Mathematical Model
    Wound Repair and RegenVol. 20 No. 1 (2012) pp. 114-122

    Abstract

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