Y. Wang, P. Paszek, C. Horton, D. Kell, M. White, D. Broomhead and M. Muldoon
Interactions among oscillatory pathways in NF- kB signalling
BMC Systems BiologyVol. 5 No. 23
AbstractSustained stimulation with tumour necrosis factor alpha (TNF-alpha) induces substantial oscillations√Ę‚?¨‚??observed at both the single cell and population levels√Ę‚?¨‚??in the nuclear factor kappa B (NF-kappa B) system. Although the mechanism has not yet been elucidated fully, a core system has been identified consisting of a negative feedback loop involving NF-kappa B (RelA:p50 hetero-dimer) and its inhibitor I-kappa B-alpha. Many authors have suggested that this core oscillator should couple to other oscillatory pathways.