MBI Publications

MBI Publications for David S. Broomhead (2)

  • Y. Wang, P. Paszek, C. Horton, D. Kell, M. White, D. Broomhead and M. Muldoon
    Interactions among oscillatory pathways in NF- kB signalling
    BMC Systems BiologyVol. 5 No. 23 (2011)


    Sustained stimulation with tumour necrosis factor alpha (TNF-alpha) induces substantial oscillationsâ???observed at both the single cell and population levelsâ???in the nuclear factor kappa B (NF-kappa B) system. Although the mechanism has not yet been elucidated fully, a core system has been identified consisting of a negative feedback loop involving NF-kappa B (RelA:p50 hetero-dimer) and its inhibitor I-kappa B-alpha. Many authors have suggested that this core oscillator should couple to other oscillatory pathways.
  • Y. Wang, P. Paszek, C. Horton, H. Yue, M. White, D. Kell, M. Muldoon, M. Muldoon and D. Broomhead
    A systematic study of the response of a NF-kB signalling pathway to TNFalpha stimulation.
    Journal of Theoretical BiololgyVol. 297 (2012) pp. 137-147


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