Videos by Workshop 3: Disease
Ionic dynamics mediate spontaneous termination of seizures and postictal depression state
Ionic concentrations fluctuate significantly during seizures. Substantial increase of extracellular K+ is found during electrically- or pharmacologically-induced paroxysmal activity, along with increase of intracellular Na+. These changes of the ionic concentrations trigger various homeostasis mechanisms such as glial uptake and Na+/K+ ATPase. While Na+/K+ ATPase is one...
Synchronized oscillations in cortico-basal ganglia circuits in Parkinson's disease
Motor symptoms of Parkinson's disease have been associated with the synchronized oscillatory activity in the cortico-basal ganglia-thalamic circuits. Here we will present our observations of the patterns of synchronized activity obtained through simultaneous intraoperative recordings of spikes and LFP in the basal ganglia and cortical EEG in parkinsonian patients. W...
On the Therapeutic Mechanisms of Deep Brain Stimulation for Parkinson's Disease: Annihilation or Restoration?
Sridevi Sarma's lecture on the Therapeutic Mechanisms of Deep Brain Stimulation for Parkinson's Disease: Annihilation or Restoration?...
Multi-scale seizure dynamics
A seizure represents an extreme deviation from normal brain activity. In this talk, we will consider some characteristics of the seizure as observed across spatial and temporal scales in human patients. We will focus specifically on changes in the rhythmic voltage activity, and consider techniques to characterize these changes. We will also discuss a mathematical model ...
Tracking dynamic rhythms in the spiking of STN neurons using point process methods
Uri Eden's lecture on tracking dynamic rhythms in the spiking of STN neurons using point process methods....