Videos by Workshop 5: Cellular and Subcellular
Mathematical analysis of depolarization block mediated by slow inactivation of the fast sodium channels that limits phasic signaling in midbrain dopamine neurons.
Dopamine neurons in freely moving rats often fire behaviorally-relevant high frequency bursts, but depolarization block limits the maximum steady firing rate of dopamine neurons in vitro to approximately 10 Hz. Using a reduced model that faithfully reproduces the sodium current measured in these neurons, we show that adding an additional slow component of sodium channel...
Structure-Preserving Model Reduction of Quasi-Active Neurons
The spatial component of input signals often carries information crucial to a neuron's function, but models which map synaptic inputs to transmembrane potential can be computationally expensive. Existing reduced models of the neuron either merge compartments, thereby sacrificing the spatial specificity of inputs, or apply model reduction techniques which sacrifice t...
Modeling calcium influx and biochemical signaling controlled by the NMDA-type glutamate receptor in postsynaptic spines
Information is stored in the brain through the formation of neural networks that encode memories. New networks are formed when the strength of synapses connecting groups of neurons increases. To achieve accurate and efficient storage of information in the brain, synaptic plasticity in the cortex and hippocampus is delicately regulated by the patterns of activity at each...