Videos by Workshop 1: Visualizing and Modeling Cellular and SubCellular Phenomena
NAD+ biosynthesis ameliorates muscular dystrophy in zebrafish
NAD+ biosynthesis ameliorates muscular dystrophy in zebrafish...
Decoupling morphogenetic tissue deformations from functional motion in cardiac development
Live microscopy allows observing rapidly moving samples, such as whole embryos during their development. Motion can be local (e.g. individual cells migrating, dividing, or contracting) or more global (e.g. induced by tissue growth or organ function). When the observed motion is induced by more than a single process or occurs at multiple temporal and spatial scales...
Tumor cell motility and invadopodia in microenvironment context
During the metastasis, tumor cells move through the primary tumor and enter blood vessels (1). Tumor cell motility has been previously investigated in details in vitro and the signaling pathways which control locomotion in 2D or invadopodia formation, which results in extracellular matrix degradation and penetration, have been dissected (2,3). However, the conditi...
Modeling the regulation of cofilin and actin based protrusion in invasive tumor cells
Modeling the regulation of cofilin and actin based protrusion in invasive tumor cells...
Modeling the regulation of cell motility in normal and cancer cells
Cell motility is coordinated by an intricate network of interacting proteins and lipids, that transduce signals into cytoskeletal reorganization, cell shape changes, and locomotion. Here I will survey some mathematical modeling that addresses both normal and aberrant cell motility. I will describe efforts in my group to construct and analyse mathematical models fo...