MBI Videos

Videos by CTW: Tissue Engineering and Regenerative Medicine

  • Directed Differentiation of Stem Cells using Lasers
    Praveen Arany
    With the renewed excitement in the inducible stem cell field, regenerative medicine is poised at our ability to efficiently direct differentiation of stem cells into functional tissues and organ systems. Besides the vast amount of work currently addressing the mechanistic underpinnings of the directed differentiation process, practical tools to harness this into a clinical...
  • Alterations in Extracellular Matrix Properties Effect Cardiac Differentiation and Cardiomyocyte Proliferation
    Lauren Black
    While the impact of single extracellular matrix (ECM) proteins and mechanical stiffness on cell function have been thoroughly probed individually, little work has been put into to understanding their interactions in the context of cell function. This is particularly important as the ECM is a complex mixture of proteins that change throughout normal development both in comp...
  • Simulating the mechanical response of fibrous scaffolds for tissue engineering
    Peter Anderson
    The use of scaffolds for tissue engineering involves aspects of mechanotransduction that are controlled by scaffold properties and structure at the local, cellular scale. For fibrous, electrospun scaffolds, such features include the local fiber stress-strain behavior, fiber density, and undulations in fiber orientation. These serve to provide variations in local stiffness ...
  • Multiscale Computational Simulations of Fiber Remodeling and Cell Compaction in Collagen Gels
    Edward Sander
    Multiscale mechanical interactions are scale spanning physical interactions between the tissue and the extracellular matrix (ECM). They are involved in a variety of biological phenomena, including tissue growth, remodeling, disease, and damage. These interactions are important to characterize because they control both the mechanical behavior of the tissue and the manner in...
  • Multiscale Models of Collagenous Materials
    Victor Barocas
    Multiscale Models of Collagenous Materials....
  • Overview of Wound Healing
    Robert Diegelman
    The normal healing response begins the moment the tissue is injured. As the blood components spill into the site of injury, the platelets come into contact with exposed collagen and other elements of the extracellular matrix. This contact triggers the platelets to release clotting factors as well as essential growth factors and cytokines such as platelet-derived growth fac...

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